Metabolite profiling of ginsenoside Rg 1  after oral administration in rat | Zendy

Wang Xiaoying | Zendy; Wang Chengcheng | Zendy; Pu Feifei | Zendy; Lin Peiyan | Zendy; Qian Tianxiu | Zendy

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Metabolite profiling of ginsenoside Rg 1 after oral administration in rat

Author(s) -

Wang Xiaoying,

Wang Chengcheng,

Pu Feifei,

Lin Peiyan,

Qian Tianxiu

Publication year - 2014

Publication title -

biomedical chromatography

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.4

H-Index - 65

eISSN - 1099-0801

pISSN - 0269-3879

DOI - 10.1002/bmc.3164

Subject(s) - metabolite , chemistry , ginsenoside , urine , in vivo , ginseng , pharmacology , biotransformation , oral administration , chromatography , biochemistry , enzyme , medicine , biology , alternative medicine , microbiology and biotechnology , pathology

The goal of this study is to investigate the biotransformation of ginsenoside Rg 1 in vivo . A highly sensitive and specific LC‐MS/MS method was developed and used for metabolite identification in rat feces and urine after oral administration of ginsenoside Rg 1 . Four metabolites of Rg 1 were detected in rat feces and three metabolites of Rg 1 were detected in rat urine. Deglycosylation and oxygenation were found to be the major metabolic pathways of ginsenoside Rg 1 after oral administration in rat. Except for the reported metabolites Rh 1 and protopanaxatriol, mono‐oxygenated Rg 1 and mono‐oxygenated protopanaxatriol were detected for the first time after oral administration of Rg 1 . The in vivo metabolite profiling of ginsenoside Rg 1 in rat was proposed. Viewed collectively, Rg 1 was metabolized to mono‐oxygenated Rg 1 , Rh 1 , protopanaxatriol and the secondary metabolite mono‐oxygenated protopanaxatriol in rat. Copyright © 2014 John Wiley & Sons, Ltd.

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