Determination of a novel diacylglycerol acyltransferase 1 inhibitor, 2‐[4‐(4‐{5‐[2‐phenyl‐5‐(trifluoromethyl) oxazole‐4‐carboxamido]‐1H‐benzo[d]imidazol‐2‐yl} phenyl) cyclohexyl] acetic acid (KR‐69232) in rat plasma using liquid chromatography–tandem mass spectrometry and its application to a pharmacokinetic study | Zendy

Seo Hyewon | Zendy; Choi Sung Heum | Zendy; Kwak EunYoung | Zendy; Zheng Zhi | Zendy; Kwak Hyun Jung | Zendy; Ahn Jin Hee | Zendy; Lee YongMoon | Zendy; Ahn SungHoon | Zendy; Bae Myung Ae | Zendy; Song Jin Sook | Zendy

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Determination of a novel diacylglycerol acyltransferase 1 inhibitor, 2‐[4‐(4‐{5‐[2‐phenyl‐5‐(trifluoromethyl) oxazole‐4‐carboxamido]‐1H‐benzo[d]imidazol‐2‐yl} phenyl) cyclohexyl] acetic acid (KR‐69232) in rat plasma using liquid chromatography–tandem mass spectrometry and its application to a pharmacokinetic study

Author(s) -

Seo Hyewon,

Choi Sung Heum,

Kwak EunYoung,

Zheng Zhi,

Kwak Hyun Jung,

Ahn Jin Hee,

Lee YongMoon,

Ahn SungHoon,

Bae Myung Ae,

Song Jin Sook

Publication year - 2014

Publication title -

biomedical chromatography

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.4

H-Index - 65

eISSN - 1099-0801

pISSN - 0269-3879

DOI - 10.1002/bmc.3053

Subject(s) - chemistry , oxazole , trifluoromethyl , chromatography , acetic acid , pharmacokinetics , stereochemistry , organic chemistry , pharmacology , medicine , alkyl

A liquid chromatography–tandem mass spectrometry method was developed and validated for the quantification of KR‐69232, a diacyltransferase 1 inhibitor, in rat plasma. KR‐69232 in the concentration range of 0.004–4 µg/mL was linear. The intra‐and inter‐day precision and accuracy were acceptable (<20%). KR‐69232 was stable under various storage and handling conditions. The method was applied successfully in a pharmacokinetic study of KR‐69232 in rats. Copyright © 2013 John Wiley & Sons, Ltd.

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