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Determination of a novel diacylglycerol acyltransferase 1 inhibitor, 2‐[4‐(4‐{5‐[2‐phenyl‐5‐(trifluoromethyl) oxazole‐4‐carboxamido]‐1H‐benzo[d]imidazol‐2‐yl} phenyl) cyclohexyl] acetic acid (KR‐69232) in rat plasma using liquid chromatography–tandem mass spectrometry and its application to a pharmacokinetic study
Author(s) -
Seo Hyewon,
Choi Sung Heum,
Kwak EunYoung,
Zheng Zhi,
Kwak Hyun Jung,
Ahn Jin Hee,
Lee YongMoon,
Ahn SungHoon,
Bae Myung Ae,
Song Jin Sook
Publication year - 2014
Publication title -
biomedical chromatography
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.4
H-Index - 65
eISSN - 1099-0801
pISSN - 0269-3879
DOI - 10.1002/bmc.3053
Subject(s) - chemistry , oxazole , trifluoromethyl , chromatography , acetic acid , pharmacokinetics , stereochemistry , organic chemistry , pharmacology , medicine , alkyl
A liquid chromatography–tandem mass spectrometry method was developed and validated for the quantification of KR‐69232, a diacyltransferase 1 inhibitor, in rat plasma. KR‐69232 in the concentration range of 0.004–4 µg/mL was linear. The intra‐and inter‐day precision and accuracy were acceptable (<20%). KR‐69232 was stable under various storage and handling conditions. The method was applied successfully in a pharmacokinetic study of KR‐69232 in rats. Copyright © 2013 John Wiley & Sons, Ltd.