Simultaneous determination of cytosine arabinoside and its metabolite, uracil arabinoside, in human plasma using hydrophilic interaction liquid chromatography with UV detection | Zendy

Uchiyama Masanobu | Zendy; Takamatsu Yasushi | Zendy; Ogata Kentaro | Zendy; Matsumoto Taichi | Zendy; Jimi Shiro | Zendy; Tamura Kazuo | Zendy; Hara Shuuji | Zendy

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Simultaneous determination of cytosine arabinoside and its metabolite, uracil arabinoside, in human plasma using hydrophilic interaction liquid chromatography with UV detection

Author(s) -

Uchiyama Masanobu,

Takamatsu Yasushi,

Ogata Kentaro,

Matsumoto Taichi,

Jimi Shiro,

Tamura Kazuo,

Hara Shuuji

Publication year - 2013

Publication title -

biomedical chromatography

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.4

H-Index - 65

eISSN - 1099-0801

pISSN - 0269-3879

DOI - 10.1002/bmc.2876

Subject(s) - chemistry , uracil , metabolite , cytosine , chromatography , human plasma , hydrophilic interaction chromatography , high performance liquid chromatography , biochemistry , dna

A practical high‐performance liquid chromatography using a Cosmosil HILIC column and UV detection was developed for determining the concentrations of cytosine arabinoside (Ara‐C) and uracil arabinoside (Ara‐U), which is a major metabolite of Ara‐C, in human plasma. This method was used to determine the plasma concentrations of Ara‐C and Ara‐U in a patient treated with high‐dose Ara‐C therapy for end‐stage renal failure. Copyright © 2013 John Wiley & Sons, Ltd.

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