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Enantioseparation of some clinically used drugs by HPLC using cellulose Tris (3,5‐dichlorophenylcarbamate) chiral stationary phase
Author(s) -
Ali Imran,
AboulEnein Hassan Y.
Publication year - 2003
Publication title -
biomedical chromatography
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.4
H-Index - 65
eISSN - 1099-0801
pISSN - 0269-3879
DOI - 10.1002/bmc.220
Subject(s) - chemistry , enantiomer , chromatography , etodolac , chiral stationary phase , chiral column chromatography , tris , metoprolol , resolution (logic) , cellulose , econazole , high performance liquid chromatography , atenolol , miconazole , pharmacology , organic chemistry , medicine , antifungal , biochemistry , dermatology , artificial intelligence , computer science , blood pressure , radiology , cardiology
The chiral resolution of some clinically used drugs namely metoprolol, teratolol, tolamolol, nebivolol (β‐adrenergic blockers), econazole, miconazole (anti‐fungal agents), cromakalim (anti‐hypertensive agent) and etodolac (anti‐inflammatory agent) was achieved on cellulose tris (3,5‐dichlorophenylcarbamate) chiral stationary phase. The mobile phase used was 2‐propanol at 0.5 mL/min with detection at 220 nm. The separation factors (α) of these drugs ranged from 1.24 to 3.90 while the resolution factors were from 1.05 to 5.0. The chiral recognition mechanisms between the racemates and the chiral selector are discussed. Copyright © 2003 John Wiley & Sons, Ltd.