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Separation of chiral 4‐substituted imidazole derivatives by cyclodextrin‐modified capillary electrophoresis †
Author(s) -
Sasse Astrid,
Schunack Walter,
Stark Holger
Publication year - 2001
Publication title -
biomedical chromatography
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.4
H-Index - 65
eISSN - 1099-0801
pISSN - 0269-3879
DOI - 10.1002/bmc.22
Subject(s) - cyclodextrin , chemistry , capillary electrophoresis , enantiomer , imidazole , chromatography , detection limit , resolution (logic) , chiral resolution , beta cyclodextrins , enantiomeric excess , organic chemistry , enantioselective synthesis , catalysis , artificial intelligence , computer science
Enantiomeric separations by cyclodextrin‐modified capillary electrophoresis of chiral carbamates containing a 4‐substituted imidazole heterocycle, pharmacologically acting as histamine H 3 ‐receptor antagonists, were carried out. Various cyclodextrins (α‐, β‐ and substituted β‐cyclodextrins) were investigated. Baseline resolution was achieved with six out of 11 compounds. Heptakis‐2,3,6‐trimethyl‐β‐cyclodextrin modified buffers seemed to be most efficient in separating most of the investigated compounds. The optical purity of one pair of enantiomers was determined. Copyright © 2001 John Wiley & Sons, Ltd. Abbreviations used: α‐CD α‐cyclodextrinβ‐CD β‐cyclodextrinCD cyclodextrinsCE capillary electrophoresisCM‐β‐CD carboxymethylated‐β‐cyclodextrinDM‐β‐CD heptakis‐2,6‐dimethyl‐β‐cyclodextrinDS average degree of substitutionee enantiomeric excessHE‐β‐CD 2‐hydroxyethyl‐β‐cyclodextrinHP‐β‐CD 2‐hydroxypropyl‐β‐cyclodextrini.d. inner diameterLOD limit of detectionLOQ limit of quantificationR s resolutionSBE‐cd sulphobutylether‐β‐cyclodextrinSO 4 ‐β‐CD sulphated‐β‐cyclodextrinTM7hyphen;β‐CD heptakis‐2,3,6‐trimethyl‐β‐cyclodextrin