Quantification of asenapine and three metabolites in human plasma using liquid chromatography–tandem mass spectrometry with automated solid‐phase extraction: application to a phase I clinical trial with asenapine in healthy male subjects | Zendy

Boer Theo | Zendy; Meulman Erik | Zendy; Meijering Henri | Zendy; Wieling Jaap | Zendy; Dogterom Peter | Zendy; Lass Holger | Zendy

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Quantification of asenapine and three metabolites in human plasma using liquid chromatography–tandem mass spectrometry with automated solid‐phase extraction: application to a phase I clinical trial with asenapine in healthy male subjects

Author(s) -

Boer Theo,

Meulman Erik,

Meijering Henri,

Wieling Jaap,

Dogterom Peter,

Lass Holger

Publication year - 2012

Publication title -

biomedical chromatography

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.4

H-Index - 65

eISSN - 1099-0801

pISSN - 0269-3879

DOI - 10.1002/bmc.1640

Subject(s) - chemistry , asenapine , chromatography , extraction (chemistry) , solid phase extraction , tandem mass spectrometry , glucuronide , mass spectrometry , liquid chromatography–mass spectrometry , metabolite , biochemistry , antipsychotic , schizophrenia (object oriented programming) , computer science , programming language

The development and validation of methods for determining concentrations of the antipsychotic drug asenapine (ASE) and three of its metabolites [ N ‐desmethylasenapine (DMA), asenapine‐N + ‐glucuronide (ASG) and 11‐ O ‐sulfate‐asenapine (OSA)] in human plasma using LC‐MS/MS with automated solid‐phase extraction is described. The three assessment methods in human plasma were found to be acceptable for quantification in the ranges 0.0250–20.0 ng/mL (ASE), 0.0500–20.0 ng/mL (DMA and OSA) and 0.250–50.0 ng/mL (ASG). Copyright © 2011 John Wiley & Sons, Ltd.

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