Analysis of  β ‐agonists by HPLC/ESI‐MS  n   in horse doping control | Zendy

Garcia P. | Zendy; Paris A.C. | Zendy; Gil J. | Zendy; Popot M.A. | Zendy; Bonnaire Y. | Zendy

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Analysis of β ‐agonists by HPLC/ESI‐MS n in horse doping control

Author(s) -

Garcia P.,

Paris A.C.,

Gil J.,

Popot M.A.,

Bonnaire Y.

Publication year - 2010

Publication title -

biomedical chromatography

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.4

H-Index - 65

eISSN - 1099-0801

pISSN - 0269-3879

DOI - 10.1002/bmc.1562

Subject(s) - chemistry , ractopamine , chromatography , formoterol , clenbuterol , fenoterol , terbutaline , salbutamol , detection limit , mass spectrometry , formoterol fumarate , inhalation , medicine , budesonide , asthma , anatomy

A sensitive method using LC/ESI‐MS n has been developed on a quadrupole linear ion trap mass analyser for the detection of nine β 2 agonists (cimaterol, clenbuterol, fenoterol, formoterol, mabuterol, terbutaline, ractopamine, salbutamol and salmeterol) in horse urine. The method consists of solid‐phase extraction on CSDAU cartridges before analysis by LC/ESI‐MS n . The efficiency of extraction combined with the sensitivity and the selectivity of MS n allowed the detection of these compounds at pg/mL levels. Administration studies of fenoterol and formoterol are reported and show their possible detection after inhalation. The method is applicable for screening and confirmatory analysis. Copyright © 2010 John Wiley & Sons, Ltd.

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