Derivatization reagents in liquid chromatography/electrospray ionization tandem mass spectrometry | Zendy

Santa Tomofumi | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Premium

Derivatization reagents in liquid chromatography/electrospray ionization tandem mass spectrometry

Author(s) -

Santa Tomofumi

Publication year - 2010

Publication title -

biomedical chromatography

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.4

H-Index - 65

eISSN - 1099-0801

pISSN - 0269-3879

DOI - 10.1002/bmc.1548

Subject(s) - derivatization , chemistry , chromatography , electrospray ionization , mass spectrometry , reagent , electrospray , tandem mass spectrometry , liquid chromatography–mass spectrometry , direct electron ionization liquid chromatography–mass spectrometry interface , chemical ionization , ionization , organic chemistry , ion

Liquid chromatography/electrospray ionization tandem mass spectrometry (LC/ESI‐MS/MS) is one of the most prominent analytical techniques owing to its inherent selectivity and sensitivity. In LC/ESI‐MS/MS, chemical derivatization is often used to enhance the detection sensitivity. Derivatization improves the chromatographic separation, and enhances the mass spectrometric ionization efficiency and MS/MS detectability. In this review, an overview of the derivatization reagents which have been applied to LC/ESI‐MS/MS is presented, focusing on the applications to low molecular weight compounds. Copyright © 2010 John Wiley & Sons, Ltd.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research