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Determination of anthocyanins in the urine of patients with colorectal liver metastases after administration of bilberry extract
Author(s) -
Cai Hong,
Thomasset Sarah C.,
Berry David P.,
Garcea Giuseppe,
Brown Karen,
Steward William P.,
Gescher Andreas J.
Publication year - 2011
Publication title -
biomedical chromatography
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.4
H-Index - 65
eISSN - 1099-0801
pISSN - 0269-3879
DOI - 10.1002/bmc.1499
Subject(s) - chemistry , vaccinium myrtillus , urine , anthocyanin , bilberry , stomach , jejunum , colorectal cancer , high performance liquid chromatography , gastroenterology , pharmacology , chromatography , cancer , medicine , biochemistry , food science , archaeology , history
Abstract Anthocyanins possess cancer chemopreventive properties in preclinical models. Their clinical pharmacology is only poorly understood. In this pilot study, anthocyanins and their metabolites were analysed in the urine of two patients with colorectal liver metastases. They received a single dose of 1.88 g standardized bilberry extract (mirtoselect) via either nasogastric or nasojejunal tube intra‐operatively during liver resection. HPLC‐MS/MS and HPLC‐UV analysis showed there were more anthocyanins and metabolites in the urine of the patient who received mirtoselect via the stomach than via the jejunum. This result is consistent with information obtained in rodents which suggests the stomach is the predominant site for anthocyanin absorption. Copyright © 2010 John Wiley & Sons, Ltd.