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Determination of medetomidine, atipamezole and midazolam in pig plasma by liquid chromatography‐mass spectrometry
Author(s) -
Kanazawa Hideko,
Nishimura Ryohei,
Sasaki Nobuo,
Takeuchi Akira,
Takai Nobuharu,
Nagata Yoshiko,
Matsushima Yoshikazu
Publication year - 1995
Publication title -
biomedical chromatography
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.4
H-Index - 65
eISSN - 1099-0801
pISSN - 0269-3879
DOI - 10.1002/bmc.1130090408
Subject(s) - atipamezole , chemistry , detomidine , chromatography , medetomidine , mass spectrometry , atmospheric pressure chemical ionization , midazolam , liquid chromatography–mass spectrometry , pharmacokinetics , chemical ionization , pharmacology , ionization , anesthesia , ion , blood pressure , medicine , heart rate , ketamine , organic chemistry , xylazine , sedation , radiology
Medetomidine, atipamezole and midazolam in pig plasma were determined by liquid chromatography‐mass spectrometry (LCMS) with an atmospheric pressure chemical ionization interface system by the use of detomidine as an internal standard. The method was applied to studies of pharmacokinetic behaviour of these drugs.