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Determination of oxeladin in human plasma by gas chromatography—mass spectrometry
Author(s) -
LartigueMattei C.,
Galmier M. J.,
Chabard J. L.,
Beyssac E.,
Aiache J. M.
Publication year - 1995
Publication title -
biomedical chromatography
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.4
H-Index - 65
eISSN - 1099-0801
pISSN - 0269-3879
DOI - 10.1002/bmc.1130090107
Subject(s) - chemistry , chromatography , mass spectrometry , human plasma , gas chromatography , gas chromatography–mass spectrometry , plasma , physics , quantum mechanics
A capillary gas chromatographic method with mass‐selective detection was developed for the determination of oxeladin in human plasma. Plasma samples (1 mL) were alkalinized and extracted using 5 mL of hexane: isoamyl alcohol (99:1). The method was demonstrated to be sensitive (limit of quantitation at 1 ng/mL), linear between 1 and 150 mg/mL, accurate and precise enough (mean error and mean coefficient of variation at the limit of quantitation were 2.3 and 13.3%, respectively) to support pharmacokinetic evaluation of the drug at doses down to 30 mg.