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Optical purity determination of thyroxine enantiomers in bulk materials by chiral thin layer chromatography
Author(s) -
AboulEnein Hassan Y.,
Serignese Vince
Publication year - 1994
Publication title -
biomedical chromatography
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.4
H-Index - 65
eISSN - 1099-0801
pISSN - 0269-3879
DOI - 10.1002/bmc.1130080616
Subject(s) - chemistry , acetonitrile , enantiomer , chromatography , solvent , thin layer chromatography , methanol , wavelength , ligand (biochemistry) , enantiomeric excess , analytical chemistry (journal) , organic chemistry , receptor , enantioselective synthesis , optoelectronics , catalysis , biochemistry , physics
L ‐thyroxine and D ‐thyroxine were separated on ligand exchange chiral thin layer chromatographic plates, using a solvent system consisting of acetonitrile:methanol:water 60:15:15 v/v, at a wavelength of 254 nm. The methodology, chiral recognition mechanism (s) involved and its application are discussed.