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Proteinergic profiles in cerebrospinal fluid from alcoholic subjects
Author(s) -
Silberring Jerzy,
Brostedt Peter,
Neiman Jack,
Hellman Ulf,
Liljequist Sture,
Terenius Lars
Publication year - 1994
Publication title -
biomedical chromatography
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.4
H-Index - 65
eISSN - 1099-0801
pISSN - 0269-3879
DOI - 10.1002/bmc.1130080309
Subject(s) - chemistry , cerebrospinal fluid , chromatography , medicine
Minute amounts of cerebrospinal fluid samples from alcoholics were subjected to separation by HPLC‐molecular sieving, combined with multispectral UV analysis of the acquired data. A significant difference in the protein/polypeptide pattern within the molecular weight range of 7–10 kDa has been observed between samples, taken directly after detoxification and 2 weeks later. Spectral analysis of the results suggests that the components are of peptidergic nature. On the other hand, albumin content did not differ significantly, suggesting that the blood–brain barrier was not affected. An enzyme marker, dynorphin converting enzyme, remained unchanged in both groups.