Rapid assay of iopanoic acid in dog plasma using a Hisep column | Zendy

Andeejani Ahmed M. I. | Zendy; Hughes Herbert | Zendy; Feuchuk Danny M. | Zendy; AboulEnein Hassan Y. | Zendy

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Rapid assay of iopanoic acid in dog plasma using a Hisep column

Author(s) -

Andeejani Ahmed M. I.,

Hughes Herbert,

Feuchuk Danny M.,

AboulEnein Hassan Y.

Publication year - 1994

Publication title -

biomedical chromatography

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.4

H-Index - 65

eISSN - 1099-0801

pISSN - 0269-3879

DOI - 10.1002/bmc.1130080107

Subject(s) - chemistry , chromatography , phosphate buffered saline , methanol , plasma , phosphate , biochemistry , organic chemistry , physics , quantum mechanics

A rapid method for the determination of iopanoic acid (IOP) in dog plasma utilizing a Hisep column was developed. A mobile phase of 12% methanol, 88% 0.05 M phosphate buffer pH 3.4 yielded a k ′ of 8.5 with no interference from proteins present in plasma. Recoveries of IOP from spiked plasma ranged from 97% to 103% at 270 μmol/L and 1.75 mmol/L respectively. Replication was ±2.8% at 1.75 mmol/L and ±6% at 21 μmol/L. A method utilizing 2,4,6‐triiodobenzoic acid as internal standard was also developed for comparison.

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