Premium
Gas chromatographic determination of mexiletine in human plasma with flame ionization detection after reaction with carbon disulphide
Author(s) -
Songgang Ji,
Qinghong Kong,
Xiulu Li,
Ping Li
Publication year - 1993
Publication title -
biomedical chromatography
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.4
H-Index - 65
eISSN - 1099-0801
pISSN - 0269-3879
DOI - 10.1002/bmc.1130070405
Subject(s) - mexiletine , chemistry , chromatography , plasma , human plasma , flame ionization detector , pharmacokinetics , gas chromatography , pharmacology , anesthesia , medicine , physics , quantum mechanics
A gas chromatographic method for the determination of mexiletine in human plasma is described. Mexiletine was simultaneously extracted and derivatized with carbon disulphide for separation and quantitation on a glass column (1.5 m × 3 mm i.d.) packed with 1.5% OV‐1 coated on 80–100 mesh Shimalite W (201D). The method required only 0.5 mL of plasma and could detect as little as 10 ng of mexiletine. It has been applied to the study of the pharmacokinetics of mexiletine in healthy volunteers.