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Determination of rafoxanide and closantel in ovine plasma by high performance liquid chromatography
Author(s) -
Benchaoui H. A.,
McKellar Q. A.
Publication year - 1993
Publication title -
biomedical chromatography
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.4
H-Index - 65
eISSN - 1099-0801
pISSN - 0269-3879
DOI - 10.1002/bmc.1130070402
Subject(s) - chemistry , chromatography , plasma , high performance liquid chromatography , quantum mechanics , physics
A high performance liquid chromatographic method has been developed for the determination of rafoxanide and closantel in ovine plasma. Acetonitrile and chloroform were used for the extraction. The mean recoveries were 78.69% and 80.59% for rafoxanide and closantel, respectively. This method was applied to the characterization of rafoxanide plasma kinetics following oral administration of therapeutic doses to sheep.