Premium
Biodegradation of a carbamate pesticide, propoxur, in rat tissues
Author(s) -
Kumar Reena,
Madhavi N. B. Bindu,
Sharma C. B.
Publication year - 1993
Publication title -
biomedical chromatography
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.4
H-Index - 65
eISSN - 1099-0801
pISSN - 0269-3879
DOI - 10.1002/bmc.1130070106
Subject(s) - propoxur , metabolite , chemistry , carbamate , pesticide , chromatography , transaminase , biochemistry , pharmacology , enzyme , biology , agronomy
Propoxur (Baygon, 2‐isopropoxyphenyl N ‐methylcarbamate) is a carbamate pesticide commonly used against house insects. When the insecticide was administered intramuscularly in rats it was converted to a new metabolite which was found to be present in the serum, liver, kidney and brain 6 h after the administration of the pesticide. The metabolite was purified by high performance liquid to chromatography and comparison of the infrared spectra of Propoxur and the metabolite showed that a deamination reaction was responsible for the formation of the metabolite from the parent pesticide. The pesticide also induced haematological changes such as an increased level of total bilubrin, amylase and glutamic–oxalacetic transaminase and decrease of cholinesterase activity, indicating damage of the liver and nervous system in rats.