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Analysis of fragrance compounds in blood samples of mice by gas chromatography, mass spectrometry, GC/FTIR and GC/AES after inhalation of sandalwood oil
Author(s) -
Jirovetz Leopold,
Buchbauer Gerhard,
Jäger Walter,
Woidich Alexander,
Nikiforov Alexej
Publication year - 1992
Publication title -
biomedical chromatography
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.4
H-Index - 65
eISSN - 1099-0801
pISSN - 0269-3879
DOI - 10.1002/bmc.1130060307
Subject(s) - chemistry , chromatography , gas chromatography , gas chromatography–mass spectrometry , mass spectrometry , coumarin , flame ionization detector , organic chemistry
Abstract After inhalation experiments with sandalwood oil and the pure fragrance compounds coumarin and α‐terpineol, substances were detected and measured in the blood samples of test animals (mice) using gas chromatography/mass spectrometry (GC/MS) (MID) in connection with GC/FTIR (SWC), GC/AES (carbon and oxygen trace) and flame ionization detection/gas chromatography. Using tiglinic acid benzyl ester as the internal standard the following concentrations in serum could be found: α‐santalol 6.1 ng/mL, β‐santalol 5.3 ng/mL and α‐santalene 0.5 ng/mL. In separate inhalation experiments with coumarin and with α‐terpineol the corresponding concentrations were 7.7 ng/mL and 6.9 ng/mL, respectively.