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Isolation of clobazam–orosomucoid complexes from Patients' sera
Author(s) -
Treuheit Michael,
Halsall H. Brian
Publication year - 1992
Publication title -
biomedical chromatography
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.4
H-Index - 65
eISSN - 1099-0801
pISSN - 0269-3879
DOI - 10.1002/bmc.1130060113
Subject(s) - orosomucoid , clobazam , chemistry , benzodiazepine , temazepam , endogeny , pharmacology , biochemistry , glycoprotein , receptor , medicine , psychiatry , epilepsy
Orosomucoid, a member of the lipocalin family, may function in the in vivo transport of lipophilic compounds such as basic and neutral drugs. We describe the identification of 7‐chloro‐1‐methyl‐1,5‐benzodiazepine‐2,4‐dione (clobazam) bound to the serum orosomucoid from individuals actively taking this tranquillizer. This suggests not only that other endogenous factors limit access to the benzodiazepine binding site on human serum albumin, but also that the differential binding of benzodiazepines and their metabolites by orosomucoid should be considered in determining therapeutic doses, particularly in the acute phase response.