Enhanced selectivity of the isolation of basic drugs from body fluids by means of extraction minicolumns and sophisticated elution schemes | Zendy

Šcoltés Ladislav | Zendy

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Enhanced selectivity of the isolation of basic drugs from body fluids by means of extraction minicolumns and sophisticated elution schemes

Author(s) -

Šcoltés Ladislav

Publication year - 1992

Publication title -

biomedical chromatography

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.4

H-Index - 65

eISSN - 1099-0801

pISSN - 0269-3879

DOI - 10.1002/bmc.1130060112

Subject(s) - chemistry , elution , sorbent , chromatography , selectivity , isolation (microbiology) , extraction (chemistry) , polar , chromatographic separation , high performance liquid chromatography , organic chemistry , adsorption , bioinformatics , physics , astronomy , biology , catalysis

The paper presents results and experience obtained in the isolation of a number of basic polar/non‐polar solutes (drugs, their metabolites and structural derivatives) from biological samples by using the separation minicolumns Separcol R SI and Separcol R SI C18 L/T. The aim was to provide insight into some simple procedures yielding optimal selectivity/specificity of the isolation of the studied solutes either by proper selection of the sorbent or by applying sophisticated elution schemes which use to advantage different properties of the eluents/solvents.

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