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Enhanced selectivity of the isolation of basic drugs from body fluids by means of extraction minicolumns and sophisticated elution schemes
Author(s) -
Šcoltés Ladislav
Publication year - 1992
Publication title -
biomedical chromatography
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.4
H-Index - 65
eISSN - 1099-0801
pISSN - 0269-3879
DOI - 10.1002/bmc.1130060112
Subject(s) - chemistry , elution , sorbent , chromatography , selectivity , isolation (microbiology) , extraction (chemistry) , polar , chromatographic separation , high performance liquid chromatography , organic chemistry , adsorption , bioinformatics , physics , astronomy , biology , catalysis
The paper presents results and experience obtained in the isolation of a number of basic polar/non‐polar solutes (drugs, their metabolites and structural derivatives) from biological samples by using the separation minicolumns Separcol R SI and Separcol R SI C18 L/T. The aim was to provide insight into some simple procedures yielding optimal selectivity/specificity of the isolation of the studied solutes either by proper selection of the sorbent or by applying sophisticated elution schemes which use to advantage different properties of the eluents/solvents.