Determination of Nifedipine in plasma by a rapid capillary gas chromatographic method | Zendy

Guellec C. Le | Zendy; Bun H. | Zendy; Giocanti M. | Zendy; Durand A. | Zendy

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Determination of Nifedipine in plasma by a rapid capillary gas chromatographic method

Author(s) -

Guellec C. Le,

Bun H.,

Giocanti M.,

Durand A.

Publication year - 1992

Publication title -

biomedical chromatography

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.4

H-Index - 65

eISSN - 1099-0801

pISSN - 0269-3879

DOI - 10.1002/bmc.1130060107

Subject(s) - chemistry , chromatography , capillary action , nifedipine , plasma , capillary gas chromatography , gas chromatography , organic chemistry , calcium , materials science , physics , quantum mechanics , composite material

A rapid, specific and reliable gas chromatographic assay procedure for Nifedipine in plasma has been developed. With a single‐step solvent extraction, and electron capture detection, the method is sensitive to 0.5 ng/mL of plasma and the standard curve is linear from 0.5 to 500 ng/mL. Samples are protected from light to prevent formation of photodecomposition products. The method has been used to monitor drug concentrations in patients receiving therapeutic doses.

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