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Determination of Nifedipine in plasma by a rapid capillary gas chromatographic method
Author(s) -
Guellec C. Le,
Bun H.,
Giocanti M.,
Durand A.
Publication year - 1992
Publication title -
biomedical chromatography
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.4
H-Index - 65
eISSN - 1099-0801
pISSN - 0269-3879
DOI - 10.1002/bmc.1130060107
Subject(s) - chemistry , chromatography , capillary action , nifedipine , plasma , capillary gas chromatography , gas chromatography , organic chemistry , calcium , materials science , physics , quantum mechanics , composite material
A rapid, specific and reliable gas chromatographic assay procedure for Nifedipine in plasma has been developed. With a single‐step solvent extraction, and electron capture detection, the method is sensitive to 0.5 ng/mL of plasma and the standard curve is linear from 0.5 to 500 ng/mL. Samples are protected from light to prevent formation of photodecomposition products. The method has been used to monitor drug concentrations in patients receiving therapeutic doses.