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Coproporphyrinogen oxidase, protoporphyrinogen oxidase and ferrochelatase activities in iron‐overloaded and ethanol‐treated rats
Author(s) -
Li Famei,
Lim C. K.,
Peters T. J.
Publication year - 1990
Publication title -
biomedical chromatography
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.4
H-Index - 65
eISSN - 1099-0801
pISSN - 0269-3879
DOI - 10.1002/bmc.1130040610
Subject(s) - protoporphyrinogen oxidase , ferrochelatase , chemistry , oxidase test , ethanol , biochemistry , enzyme , heme
The activities of coproporphyrinogen oxidase, protoporphyrinogen oxidase and ferrochelatase in liver homogenates of iron‐overloaded and acutely or chronically ethanol‐treated rats were assayed by high performance liquid chromatographic methods. Decreased coproporphyrinogen oxidase activity was found in chronically carbonyliron‐fed rats while the activities of protoporphyrinogen oxidase and ferrochelatase remained unchanged. Coproporphyrinogen oxidase and protoporphyrinogen oxidase activities in both chronically and actuely ethanol‐treated animals were not significantly different from controls. In chronically ethanol‐fed rats normal ferrochelatase activity was found.