Solid phase extraction and high performance liquid chromatographic determination of doxophylline in plasma | Zendy

Lagana A. | Zendy; Bizzarri M. | Zendy; Marino A. | Zendy; Mancini M. | Zendy

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Solid phase extraction and high performance liquid chromatographic determination of doxophylline in plasma

Author(s) -

Lagana A.,

Bizzarri M.,

Marino A.,

Mancini M.

Publication year - 1990

Publication title -

biomedical chromatography

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.4

H-Index - 65

eISSN - 1099-0801

pISSN - 0269-3879

DOI - 10.1002/bmc.1130040507

Subject(s) - chromatography , chemistry , extraction (chemistry) , plasma , solid phase extraction , phase (matter) , organic chemistry , physics , quantum mechanics

A sensitive and selective high performance liquid chromatographic doxophylline assay with ultraviolet detection has been developed for plasma samples. The drug is isolated from biological samples with a reversed phase C 18 disposable extraction column. Plasma standard curves are linear for concentrations of doxophylline from 0.03 to 10 mg/L. At the therapeutic range concentrations, the recoveries are better than 96.9%. The coefficients of variation for the procedure are 4.1% and 2.7% for the concentrations 0.03 mg/L and 10 mg/L, respectively. By this method, pharmacokinetic profiles are obtained for six adult volunteers.

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