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Studies on the determination and degradation of pyrimethamine in mammals
Author(s) -
Kumar Reena,
Kaushik P.,
Sharma C. B.
Publication year - 1990
Publication title -
biomedical chromatography
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.4
H-Index - 65
eISSN - 1099-0801
pISSN - 0269-3879
DOI - 10.1002/bmc.1130040411
Subject(s) - pyrimethamine , metabolite , chemistry , chromatography , drug , in vitro , quantitative analysis (chemistry) , blood plasma , pharmacology , plasma concentration , thin layer , biological fluids , biochemistry , layer (electronics) , immunology , malaria , plasmodium falciparum , biology , organic chemistry
Treatment of pyrimethamine with blood plasma in vitro yields a metabolite which is also produced when the drug is administered through intravenous injection in the rat. A thin layer liquid chromatographic method for quantitative and qualitative determination of pyrimethamine and its metabolite in plasma and biological tissues is described.