High performance liquid chromatography determination of doxorubicin and daunorubicin in plasma using UV detection and column switching | Zendy

Mikan A. | Zendy; Lanao J. Martinez | Zendy; Lopez F. Gonzalez | Zendy; Hurle A. DominguezGil | Zendy

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High performance liquid chromatography determination of doxorubicin and daunorubicin in plasma using UV detection and column switching

Author(s) -

Mikan A.,

Lanao J. Martinez,

Lopez F. Gonzalez,

Hurle A. DominguezGil

Publication year - 1990

Publication title -

biomedical chromatography

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.4

H-Index - 65

eISSN - 1099-0801

pISSN - 0269-3879

DOI - 10.1002/bmc.1130040408

Subject(s) - daunorubicin , chemistry , chromatography , doxorubicin , detection limit , plasma , coefficient of variation , high performance liquid chromatography , chemotherapy , medicine , physics , surgery , quantum mechanics

A method for the determination of doxorubicin and daunorubicin in plasma is described. The plasma is injected directly into a loop column and then washed with water. After switching the injection valve, the sample is separated on a phenyl column using detection at 254 nm. The detection limit is 10 ng/mL, the coefficient of variation is 7% for 100 ng/mL of doxorubicin and 4% for 200 ng/mL of daunorubicin.

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