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Identification of isoprenoid‐type components in human expired air: A possible shunt pathway in sterol metabolism
Author(s) -
O'Neill Hugh J.,
Gordon Sydney M.,
Krotoszynski Boguslaw,
Kavin Hymie,
Szidon Jan P.
Publication year - 1987
Publication title -
biomedical chromatography
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.4
H-Index - 65
eISSN - 1099-0801
pISSN - 0269-3879
DOI - 10.1002/bmc.1130020206
Subject(s) - sterol , chemistry , terpenoid , baboon , metabolism , biochemistry , cholesterol , stereochemistry , chromatography , biology , endocrinology
Expired air samples have been analyzed from three groups of human subjects (normal, liver dysfunction, lung cancer) and the baboon ( Papio anubus ). Of the several hundred compounds present, three compounds were of particular interest due to their structural relationship to the isoprenoid‐type intermediates in the sterol pathway. These compounds were 1‐methyl‐4‐(1‐methyl‐ethenyl)‐cyclohexene, 6‐methyl‐5‐hepten‐2‐one, and 6,10‐dimethyl‐5,9‐undecadien‐2‐one. Hydroxyacetone was also found in all samples screened. The relationship of these compounds to the non‐sterol pathway of mevalonate metabolism is discussed.