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Direct TLC resolution of atenolol and propranolol into their enantiomers using three different chiral selectors as impregnating reagents
Author(s) -
Bhushan Ravi,
Tanwar Shivani
Publication year - 2008
Publication title -
biomedical chromatography
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.4
H-Index - 65
eISSN - 1099-0801
pISSN - 0269-3879
DOI - 10.1002/bmc.1025
Subject(s) - chemistry , enantiomer , chromatography , detection limit , atenolol , tartaric acid , resolution (logic) , reagent , mandelic acid , silica gel , solvent , organic chemistry , medicine , artificial intelligence , computer science , blood pressure , citric acid , radiology
Direct resolution of racemic atenolol and propranolol into their enantiomers was achieved by normal phase TLC on silica gel plates impregnated with optically pure l ‐tartaric acid, ( R )‐mandelic acid and (–)‐erythromycin as chiral selectors. Different solvent systems were worked out to resolve the enantiomers. Spots were detected using iodine vapour. The TLC method was validated for linearity, limit of detection and limit of quantification. The influence of pH, temperature and concentration of chiral selector was studied. Copyright © 2008 John Wiley & Sons, Ltd.