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A course‐based undergraduate research experience investigating the consequences of nonconserved mutations in lactate dehydrogenase
Author(s) -
Ayella Allan,
Beck Moriah R.
Publication year - 2018
Publication title -
biochemistry and molecular biology education
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.34
H-Index - 39
eISSN - 1539-3429
pISSN - 1470-8175
DOI - 10.1002/bmb.21115
Subject(s) - function (biology) , institution , variety (cybernetics) , lactate dehydrogenase , undergraduate research , medical education , biochemistry , psychology , engineering ethics , biology , mathematics education , genetics , sociology , enzyme , computer science , medicine , engineering , social science , artificial intelligence
There is a growing movement to involve undergraduate students in authentic research experiences. A variety of studies have indicated the strength of this approach in developing scientific aptitude, confidence, critical thinking skills, and increasing the likelihood to become career scientists. Course‐based undergraduate research experiences (CUREs) foster opportunities for students to carry out authentic research at both primarily undergraduate and large research institutions. Here, we describe a novel CURE‐based biochemistry laboratory course to explore the consequences of mutagenesis of non‐conserved amino acid sites in the structure and function of the lactate dehydrogenase enzyme and demonstrate how collaborations between institutions can facilitate real research experiences at any type of institution. © 2018 by The International Union of Biochemistry and Molecular Biology, 46(3):285–296, 2018.