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Students' understanding of external representations of the potassium ion channel protein part II: Structure–function relationships and fragmented knowledge
Author(s) -
Harle Marissa,
Towns Marcy H.
Publication year - 2012
Publication title -
biochemistry and molecular biology education
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.34
H-Index - 39
eISSN - 1539-3429
pISSN - 1470-8175
DOI - 10.1002/bmb.20620
Subject(s) - polarity (international relations) , function (biology) , ion channel , set (abstract data type) , potassium channel , ribbon , psychology , chemistry , biophysics , cognitive science , mathematics education , computer science , biochemistry , biology , cell , microbiology and biotechnology , materials science , receptor , composite material , programming language
Research that has focused on external representations in biochemistry has uncovered student difficulties in comprehending and interpreting external representations. This study focuses on students' understanding of three external representations (ribbon diagram, wireframe, and hydrophobic/hydrophilic) of the potassium ion channel protein. Analysis of the interview data demonstrates that students were able to use the ribbon structures and polarity of the cell membrane to help support claims about the protein's orientation and interactions within the cell membrane. Students expressed fragmented understandings of the interactions between the potassium ion and the aqueous solution outside/inside of the cell membrane. Suggestions for instruction are to probe student understanding to help students activate prior knowledge and to help them build a more connected set of concepts pertaining to protein structure and function.