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First steps in computational systems biology: A practical session in metabolic modeling and simulation
Author(s) -
ReyesPalomares Armando,
SánchezJiménez Francisca,
Medina Miguel Ángel
Publication year - 2009
Publication title -
biochemistry and molecular biology education
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.34
H-Index - 39
eISSN - 1539-3429
pISSN - 1470-8175
DOI - 10.1002/bmb.20281
Subject(s) - systems biology , computer science , session (web analytics) , modelling biological systems , plan (archaeology) , management science , computational biology , biology , engineering , paleontology , world wide web
A comprehensive understanding of biological functions requires new systemic perspectives, such as those provided by systems biology. Systems biology approaches are hypothesis‐driven and involve iterative rounds of model building, prediction, experimentation, model refinement, and development. Developments in computer science are allowing for ever faster numerical simulations of mathematical models. Mathematical modeling plays an essential role in new systems biology approaches. As a complex, integrated system, metabolism is a suitable topic of study for systems biology approaches. However, up until recently, this topic has not been properly covered in biochemistry courses. This communication reports the development and implementation of a practical lesson plan on metabolic modeling and simulation.