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Copper‐catalyzed Regioselective Hydroaminations of Allylic Sulfones With Aromatic Amines
Author(s) -
Kim Kundo,
Cho Soohong,
Park Subin,
Lee Yunmi
Publication year - 2021
Publication title -
bulletin of the korean chemical society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.237
H-Index - 59
ISSN - 1229-5949
DOI - 10.1002/bkcs.12264
Subject(s) - regioselectivity , allylic rearrangement , amination , chemistry , copper , catalysis , carbene , combinatorial chemistry , reaction conditions , organic chemistry , medicinal chemistry
The highly regioselective copper‐catalyzed hydroaminations of terminal or γ‐substituted allylic sulfones with aromatic amines is described. The combination of an N ‐heterocyclic carbene‐copper complex and KO t ‐Bu plays an important role in promoting selective amination under mild reaction conditions. This catalytic reaction tolerates a wide range of functional groups and enables the efficient syntheses of new and versatile functionalized β‐amino sulfones in high yields (up to 98%) with >98% regioselectivity.