Premium
Construction of a Quinoline‐based Sequential Functioning Chromogenic Sensor for Copper( II ) Ion and Biothiols: Its Application to Test Strips
Author(s) -
So Haeri,
Park Soyoung,
Kim Cheal
Publication year - 2021
Publication title -
bulletin of the korean chemical society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.237
H-Index - 59
ISSN - 1229-5949
DOI - 10.1002/bkcs.12255
Subject(s) - chromogenic , copper , chemistry , titration , quinoline , moiety , absorption (acoustics) , detection limit , ion , inorganic chemistry , nuclear chemistry , stereochemistry , chromatography , organic chemistry , materials science , composite material
A new compound BQ ((1E,1'E)‐ N ,N'‐((1,3‐phenylenebis(oxy))bis(3,1‐phenylene))bis(1‐(quinolin‐2‐yl)methanimine)) containing quinoline moiety has been developed as a sequential functioning chromogenic sensor for copper(II) ion and biological thiols (GSH, Cys, and Hcy). BQ had a clear chromogenic response toward only copper ion with a red‐shifted absorption. Detection limit for copper(II) ion was calculated to be 1.20 μM. Its application was successfully conducted in test strips. The resultant BQ‐Cu 2+ complex could detect the biological thiols, showing the color change and blue‐shifted absorption via the demetallation of copper(II) ion. The possible binding mechanisms of BQ to copper(II) ion and of BQ ‐Cu 2+ to biological thiols were understood by UV–vis titrations, Job plot, ESI‐MS, and 1 H NMR titrations.