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Synthesis of Idebenonyl Ester Prodrugs and Their Evaluation of Cancer Cells In Vitro
Author(s) -
Bae Song Mi,
Choi Se Myeong,
Won Yeongseon,
Seo Kwonil,
Jung Dai il,
Song Ju Hyun,
Cho Jong Hyun
Publication year - 2021
Publication title -
bulletin of the korean chemical society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.237
H-Index - 59
ISSN - 1229-5949
DOI - 10.1002/bkcs.12246
Subject(s) - prodrug , chemistry , in vitro , yield (engineering) , viability assay , nonsteroidal , cancer cell , stereochemistry , organic chemistry , biochemistry , combinatorial chemistry , cancer , pharmacology , biology , materials science , metallurgy , genetics
Esterification of idebenone with commercially available straight‐chain aliphatic acids, branched‐chain aliphatic acids, aromatic acids, or nonsteroidal anti‐inflammatory drugs afforded their corresponding idebenonyl esters ( 5a – k ) in good yield. The values of cell viability for RC‐58T cell at 50 μM were 86.3% for 5a , 75.9% for 5b , 23.4% for 5d , 61.2% for 5f , 67.9% for 5h , 70.6% for 5i , and 49.0% for 5j .