Synthesis of Idebenonyl Ester Prodrugs and Their Evaluation of Cancer Cells  In Vitro | Zendy

Bae Song Mi | Zendy; Choi Se Myeong | Zendy; Won Yeongseon | Zendy; Seo Kwonil | Zendy; Jung Dai il | Zendy; Song Ju Hyun | Zendy; Cho Jong Hyun | Zendy

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Synthesis of Idebenonyl Ester Prodrugs and Their Evaluation of Cancer Cells In Vitro

Author(s) -

Bae Song Mi,

Choi Se Myeong,

Won Yeongseon,

Seo Kwonil,

Jung Dai il,

Song Ju Hyun,

Cho Jong Hyun

Publication year - 2021

Publication title -

bulletin of the korean chemical society

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.237

H-Index - 59

ISSN - 1229-5949

DOI - 10.1002/bkcs.12246

Subject(s) - prodrug , chemistry , in vitro , yield (engineering) , viability assay , nonsteroidal , cancer cell , stereochemistry , organic chemistry , biochemistry , combinatorial chemistry , cancer , pharmacology , biology , materials science , metallurgy , genetics

Esterification of idebenone with commercially available straight‐chain aliphatic acids, branched‐chain aliphatic acids, aromatic acids, or nonsteroidal anti‐inflammatory drugs afforded their corresponding idebenonyl esters ( 5a – k ) in good yield. The values of cell viability for RC‐58T cell at 50 μM were 86.3% for 5a , 75.9% for 5b , 23.4% for 5d , 61.2% for 5f , 67.9% for 5h , 70.6% for 5i , and 49.0% for 5j .

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