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Synthesis of a DNA‐Encoded Library of Pyrrolo[2,3 ‐d ]pyrimidines
Author(s) -
Park Jun Hyung,
Wang Hee Myeong,
Shin Min Hyeon,
Lim HyunSuk
Publication year - 2021
Publication title -
bulletin of the korean chemical society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.237
H-Index - 59
ISSN - 1229-5949
DOI - 10.1002/bkcs.12243
Subject(s) - dna , drug discovery , computational biology , combinatorial chemistry , synthetic biology , dna synthesis , chemistry , biology , biochemistry
Developing DNA‐encoded libraries of privileged scaffolds, such as pyrrolopyrimidines, is of great interest in drug discovery and chemical biology as a powerful tool to rapidly and inexpensively discover potent drug candidates. However, it is often challenging to construct such DNA‐encoded libraries because many reaction conditions are not compatible with DNA. Here, we describe the development of a convenient solid‐phase synthetic strategy that overcomes the current limitations and allows the efficient synthesis of a DNA‐encoded combinatorial library of structurally diverse tetra‐substituted pyrrolo[2,3 ‐d ]pyrimidines.