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Metabolomic Study of Normal and Modified Nucleosides in the Urine of Mice with Lipopolysaccharide‐Induced Sepsis by LC–MS / MS
Author(s) -
Ji Moongi,
Lee HyeonSeong,
Kim Youngbae,
Seo Chan,
Oh Songjin,
Jung In Duk,
Park JaeHyun,
Paik ManJeong
Publication year - 2021
Publication title -
bulletin of the korean chemical society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.237
H-Index - 59
ISSN - 1229-5949
DOI - 10.1002/bkcs.12240
Subject(s) - sepsis , lipopolysaccharide , urine , metabolomics , nucleoside , chemistry , mass spectrometry , endogeny , pharmacology , liquid chromatography–mass spectrometry , chromatography , biochemistry , medicine , immunology
Endogenous normal and modified nucleosides have been studied as potential biomarkers of various inflammatory diseases including sepsis. However, no systematic nucleoside profiling and pattern analysis study has been performed in sepsis. In this study, simultaneous liquid chromatography–mass spectrometry profiling of normal and modified nucleosides was performed to characterize altered nucleoside metabolism in sepsis mice.