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Visible Light‐Induced Intramolecular C─O Bond Formation via 1, 5‐Hydrogen Atom Transfer Strategy
Author(s) -
Kim Kiho,
Kim Namhoon,
Hong Sungwoo
Publication year - 2021
Publication title -
bulletin of the korean chemical society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.237
H-Index - 59
ISSN - 1229-5949
DOI - 10.1002/bkcs.12234
Subject(s) - intramolecular force , chemistry , alkoxy group , ether , hydrogen atom , hydrogen bond , photochemistry , stereochemistry , molecule , alkyl , organic chemistry
An efficient strategy for the visible‐light‐promoted intramolecular C─O bond formation has been accomplished, which allows the synthesis of cyclic ether derivatives in the absence of a photocatalyst. This reaction is likely to occur through the generation of alkoxy radical from in situ generated O─I bond, followed by 1,5‐hydrogen atom transfer (1,5‐HAT) and subsequent intramolecular cyclization to form a C─O bond. This synthetic approach offers an efficient tool by providing access to valuable cyclic ether scaffolds under mild reaction conditions.