Premium
Ruthenium( II )‐Catalyzed CH/NH Carbonylative Cyclization of 2‐Aryl Quinazolinones with Isocyanates as CO Surrogates
Author(s) -
Choi Jin Ho,
Do Kim Hak,
Kang Ju Young,
Jeong Taejoo,
Ghosh Prithwish,
Kim In Su
Publication year - 2021
Publication title -
bulletin of the korean chemical society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.237
H-Index - 59
ISSN - 1229-5949
DOI - 10.1002/bkcs.12228
Subject(s) - ruthenium , carbonylation , chemistry , aryl , catalysis , annulation , intramolecular force , combinatorial chemistry , substrate (aquarium) , functional group , medicinal chemistry , stereochemistry , organic chemistry , carbon monoxide , alkyl , oceanography , polymer , geology
The ruthenium(II)‐catalyzed CH carbonylation of 2‐aryl quinazolinones with isocyanates as carbonyl sources is described. The developed method provides direct access to biologically relevant isoindoloquinazolinone core through CH aminocarbonylation followed by intramolecular annulation. A broad range of substrate scope and functional group tolerance were observed. Gram‐scale reactions and synthetic transformations demonstrate the synthetic potential of this protocol.