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Two Facile General Methods for the Conjugation of Three Different Molecules
Author(s) -
Oh Keumrok,
Shin Dong Seok,
Kim Hyeong Baik,
Sirion Uthaiwan,
Chi Dae Yoon
Publication year - 2021
Publication title -
bulletin of the korean chemical society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.237
H-Index - 59
ISSN - 1229-5949
DOI - 10.1002/bkcs.12208
Subject(s) - alkyne , azide , chemistry , bioconjugation , combinatorial chemistry , amine gas treating , click chemistry , copper , molecule , cycloaddition , isothiocyanate , catalysis , coupling reaction , organic chemistry
In the quest to synthesize compounds that are uniquely optimized for fighting each individual target disease, the importance of developing a new methodology for the bioconjugation of compounds with different functional groups or biological activities cannot be overemphasized. This study investigates two novel methods for click reaction: coupling a molecule with three functional compounds by repetitive copper(I) catalyzed azide/alkyne 1,3‐dipolar cycloadditions. Method A uses three copper(I) catalyzed azide/alkyne 1,3‐dipolar cycloadditions in series. Method B uses two copper(I) catalyzed azide/alkyne 1,3‐dipolar cycloadditions and one conjugation reaction of amine and isothiocyanate.