Two Facile General Methods for the Conjugation of Three Different Molecules | Zendy

Oh Keumrok | Zendy; Shin Dong Seok | Zendy; Kim Hyeong Baik | Zendy; Sirion Uthaiwan | Zendy; Chi Dae Yoon | Zendy

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Two Facile General Methods for the Conjugation of Three Different Molecules

Author(s) -

Oh Keumrok,

Shin Dong Seok,

Kim Hyeong Baik,

Sirion Uthaiwan,

Chi Dae Yoon

Publication year - 2021

Publication title -

bulletin of the korean chemical society

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.237

H-Index - 59

ISSN - 1229-5949

DOI - 10.1002/bkcs.12208

Subject(s) - alkyne , azide , chemistry , bioconjugation , combinatorial chemistry , amine gas treating , click chemistry , copper , molecule , cycloaddition , isothiocyanate , catalysis , coupling reaction , organic chemistry

In the quest to synthesize compounds that are uniquely optimized for fighting each individual target disease, the importance of developing a new methodology for the bioconjugation of compounds with different functional groups or biological activities cannot be overemphasized. This study investigates two novel methods for click reaction: coupling a molecule with three functional compounds by repetitive copper(I) catalyzed azide/alkyne 1,3‐dipolar cycloadditions. Method A uses three copper(I) catalyzed azide/alkyne 1,3‐dipolar cycloadditions in series. Method B uses two copper(I) catalyzed azide/alkyne 1,3‐dipolar cycloadditions and one conjugation reaction of amine and isothiocyanate.

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