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Palladium‐catalyzed Aerobic Benzannulation of Pyrazoles with Alkynes
Author(s) -
Song Jae Yeong,
Jang Jin Hyeok,
Chuang ShihChing,
Joo Jung Min
Publication year - 2021
Publication title -
bulletin of the korean chemical society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.237
H-Index - 59
ISSN - 1229-5949
DOI - 10.1002/bkcs.12175
Subject(s) - annulation , catalysis , chemistry , palladium , acetic acid , stoichiometry , sodium acetate , combinatorial chemistry , molecular oxygen , organic chemistry
As an alternative to a stoichiometric metal oxidant, oxygen was used as an oxidant for Pd‐catalyzed annulation reactions of pyrazoles with internal alkynes. The addition of sodium acetate and acetic acid was critical for stabilizing the Pd system. This green approach allowed the preparation of indazoles from readily available parent pyrazoles in a single step.