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Reactivity of Flavonoids Containing a Catechol or Pyrogallol Moiety with Metal‐Free and Metal‐Associated Amyloid‐β
Author(s) -
Park Seongmin,
Yi Yelim,
Lim Mi Hee
Publication year - 2021
Publication title -
bulletin of the korean chemical society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.237
H-Index - 59
ISSN - 1229-5949
DOI - 10.1002/bkcs.12172
Subject(s) - pyrogallol , catechol , chemistry , metal , reactivity (psychology) , moiety , reagent , organic chemistry , medicine , alternative medicine , pathology
Aggregates of both metal‐free amyloid‐β (Aβ) and metal‐bound Aβ (metal–Aβ) are accumulated in the brain affected by Alzheimer's disease. To control metal‐free and metal‐bound Aβ species, chemical reagents capable of modulating their aggregation profiles have been developed. As an effort, the reactivity of natural products such as flavonoids with metal‐free Aβ and metal–Aβ has been investigated to identify their use as chemical reagents and structural features essential for such reactivity. This review illustrates the effects of flavonoids containing a catechol or pyrogallol group on metal‐free and metal‐mediated Aβ aggregation pathways. In addition, the studies regarding the structure–activity relationship of flavonoids against metal‐free Aβ or metal–Aβ are discussed.