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Choline Hydroxide as a Versatile Medium for Catalyst‐Free O ‐Functionalization of Phenols
Author(s) -
Kwon GyuTae,
Joo SeongRyu,
Park SooYoul,
Kim SeungHoi
Publication year - 2020
Publication title -
bulletin of the korean chemical society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.237
H-Index - 59
ISSN - 1229-5949
DOI - 10.1002/bkcs.12138
Subject(s) - phenol , ionic liquid , hydroxide , catalysis , surface modification , chemistry , alkylation , phenols , choline , ether , organic chemistry , combinatorial chemistry , biochemistry
A versatile synthetic protocol for benzyl phenyl ether preparation via O ‐alkylation of phenolic oxygen with readily available benzyl derivatives was demonstrated. The newly designed procedure was carried out using an eco‐friendly medium, room‐temperature ionic liquid (choline hydroxide), under metal‐ and base‐catalyst‐free aerobic conditions. The reaction platform was also successfully applied to phenol protection strategy.