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Chimeric crRNAs Retaining Activity of Cas12a with Potential to Improve Specificity
Author(s) -
Park Jihyun,
Choi Jaewoo,
Duong Men Thi Hoai,
Ahn HeeChul,
Hong Seung Woo,
Hwang Gil Tae,
An Jinsu,
Chung Hak Suk,
Ahn DaeRo
Publication year - 2021
Publication title -
bulletin of the korean chemical society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.237
H-Index - 59
ISSN - 1229-5949
DOI - 10.1002/bkcs.12109
Subject(s) - trans activating crrna , rna , computational biology , chemistry , computer science , crispr , biology , biochemistry , gene , cas9
RNA residues in the guide region of crRNA for Cas12a can be partially replaced by DNA.