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Microwave‐assisted Synthesis and Molecular Docking Study of Heteroaromatic Chalcone Derivatives as Potential Antibacterial Agents
Author(s) -
Farooq Saba,
Ngaini Zainab,
Mortadza Nur Arif
Publication year - 2020
Publication title -
bulletin of the korean chemical society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.237
H-Index - 59
ISSN - 1229-5949
DOI - 10.1002/bkcs.12088
Subject(s) - chalcone , chemistry , antibacterial activity , pyrazoline , yield (engineering) , staphylococcus aureus , combinatorial chemistry , microwave , condensation reaction , stereochemistry , nuclear chemistry , organic chemistry , bacteria , catalysis , materials science , genetics , physics , quantum mechanics , metallurgy , biology
In this study, a series of chalcone derivatives ( 1a–c ) were synthesized via Claisen‐Schmidt condensation, followed by aza‐Michael addition to form pyrazoline derivatives ( 2a–c and 3a–c ). The reaction was performed via microwave radiation to give excellent yields (77–93%) in 1–3.5 min. Microwave‐assisted reaction of Fischer esterification of pyrazolines ( 2a–c and 3a–c ) afforded heteroaromatic pyrazoline esters ( 4a–c ) in high yield (83–96% in <2 min) compared to conventional reflux (55–79% in 30 min). Compounds 1a–c and 3a–c demonstrated excellent antibacterial activity against Staphylococcus aureus via disc diffusion assay with inhibition zone with 13 and 19 mm compared to a standard drug, ampicillin (11 mm). Structure activity relationship of 1b and 3b were visualized via molecular docking interaction against 4pql protein of S. aureus with binding free energy −7.0 and −8.0 kcal/mol, respectively. This study is significant in drug discovery process particularly for pharmaceutical industries.