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Cytoprotective Coating of HeLa Cells with Titanium Dioxide
Author(s) -
Kim Doyeon,
Lee Juno,
Choi Jinsu,
Yang Sung Ho
Publication year - 2020
Publication title -
bulletin of the korean chemical society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.237
H-Index - 59
ISSN - 1229-5949
DOI - 10.1002/bkcs.12077
Subject(s) - coating , hela , titanium dioxide , surface modification , chemistry , abiotic component , titanium , biophysics , materials science , chemical engineering , nanotechnology , biochemistry , cell , organic chemistry , biology , composite material , paleontology , engineering
Cytoprotective coating of mammalian cells with inorganic materials has been intensively studied with aims of functionalization and bioapplication of the cells. It is more difficult to coat mammalian cells with abiotic materials than biogenic ones because of incompatibility of abiotic ones as well as the fragility of mammalian cells. In this work, it was demonstrated that HeLa cells were coated with abiotic inorganic materials, titanium dioxide, by rigorously optimizing layer‐by‐layer process that ensures cytocompatibility. As a result, the adherent nature of the cells changed to the floating because of mechanical robustness of the coating. In addition, titanium dioxide coat protected the cells from UV‐C irradiation, which implied that the photo‐screening function of titanium dioxide was implanted to mammalian cells.