Premium
Diversification of Heteroaryl‐Aryl Ether via Ligand‐Free, Copper‐Catalyzed O ‐Arylation Under Microwave Heating
Author(s) -
Choi Sung Min,
Byeon Jeong Seob,
Yum Eul Kgun
Publication year - 2020
Publication title -
bulletin of the korean chemical society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.237
H-Index - 59
ISSN - 1229-5949
DOI - 10.1002/bkcs.12075
Subject(s) - catalysis , aryl , chemistry , ether , pyridine , ligand (biochemistry) , microwave , copper , oxidative phosphorylation , combinatorial chemistry , pyrimidine , organic chemistry , stereochemistry , receptor , biochemistry , alkyl , physics , quantum mechanics
Diverse O ‐arylated pyrrolo[2,3‐ d ]pyrimidine and pyrrolo[2,3‐ b ]pyridine were obtained using relatively low amounts of Cu catalyst with ligand‐free conditions under microwave heating. The O ‐arylation reaction could be applied to less oxidative heteroaryl‐chlorides. The microwave‐assisted Cu‐catalyzed O ‐aryaltion would be useful for preparing potent bioactive compounds for drug discovery while reducing waste, time, and saving energy.