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A Novel Paramagnetic Nanoparticle T 2 Magnetic Resonance Imaging Contrast Agent With High Colloidal Stability: Polyacrylic Acid‐Coated Ultrafine Dysprosium Oxide Nanoparticles
Author(s) -
Marasini Shanti,
Yue Huan,
Ho Son Long,
Cha Hyunsil,
Park Ji Ae,
Jung KiHye,
Ghazanfari Adibehalsadat,
Ahmad Mohammad Yaseen,
Liu Shuwen,
Chae KwonSeok,
Chang Yongmin,
Lee Gang Ho
Publication year - 2020
Publication title -
bulletin of the korean chemical society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.237
H-Index - 59
ISSN - 1229-5949
DOI - 10.1002/bkcs.12074
Subject(s) - dysprosium , polyacrylic acid , paramagnetism , nanoparticle , mri contrast agent , nuclear magnetic resonance , biocompatibility , colloid , gadolinium , chemistry , materials science , magnetic resonance imaging , in vivo , nuclear chemistry , nanotechnology , inorganic chemistry , polymer , organic chemistry , medicine , physics , microbiology and biotechnology , quantum mechanics , biology , radiology
Until now, there have been limited studies on T 2 magnetic resonance imaging (MRI) contrast agents (CAs) using paramagnetic nanoparticles (NPs). In this study, ultrafine dysprosium oxide (Dy 2 O 3 ) NPs were synthesized as a T 2 MRI CA. To obtain high biocompatibility and colloidal stability in aqueous medium for in vivo applications, they were grafted with polyacrylic acid. They displayed paramagnetism with an appreciable magnetization value at 300 K and consequently, an appreciable transverse water proton spin relaxivity (r 2 ) value which increased as the applied MR field increased. Their potential as a T 2 MRI CA was proved by taking in vivo T 2 MR images in mice.