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Optimization of the Synthesis of 18 F‐D 2 ‐Deprenyl With Mild 18 F ‐Fluorination and Minimum Precursor Input for PET Imaging of Neuroinflammation
Author(s) -
Lee Sang Ju,
Ko Na Re,
Oh Seung Jun
Publication year - 2020
Publication title -
bulletin of the korean chemical society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.237
H-Index - 59
ISSN - 1229-5949
DOI - 10.1002/bkcs.12071
Subject(s) - yield (engineering) , chemistry , molar ratio , specific activity , elution , nuclear chemistry , radiochemistry , chromatography , catalysis , enzyme , organic chemistry , materials science , metallurgy
Here, we established optimized conditions for a mild 18 F‐fluorination to yield 18 F‐deprenyl and 18 F‐D 2 ‐deprenyl as neuroinflammation imaging agents by fully automatic synthesis. Initially, manual synthesis with 1 mg of precursor and pH = 7.8 KOMs elution buffer yielded 85–92% of 18 F‐incorporation yields and showed nondecay corrected yields of 15–17%. Fully automatic synthesis showed a nondecay corrected radiochemical yield of 10.7 ± 0.46%. Owing to low precursor input, the maximum molar activity achieved was 1302.4 ± 26.4 GBq/μmol. Our mild 18 F‐fluorination procedure showed higher radiochemical yields and molar activity than those by previously used procedures, even with minimized precursor input.