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Synthesis and Antiepileptic Activity Evaluation of Valproic Acid Derivatives by Niche Chemistry
Author(s) -
Song Ju Hyun,
Bae Song Mi,
Bae Whae Ran,
Huh Jin Sun,
Chen Yu,
Jeong Il Soo,
Jung Dai Il
Publication year - 2020
Publication title -
bulletin of the korean chemical society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.237
H-Index - 59
ISSN - 1229-5949
DOI - 10.1002/bkcs.12010
Subject(s) - valproic acid , chemistry , combinatorial chemistry , derivative (finance) , organic chemistry , epilepsy , neuroscience , financial economics , economics , biology
In order to prepare new antiepileptic drugs with a broader clinical application and lower toxic side effects, we have employed esterification and condensation reactions (we call it Niche Chemistry) to reduce the use of valproic acid as the target molecule. In combination with the study of a broad‐spectrum of novel anticonvulsants, we have synthesized two valeric acid derivative compounds [(4‐acetamidophenyl 2‐propylvalerate ( 1 ), and (E)‐5‐(4‐((2‐propylpentanoyl)oxy)styryl)‐1,3‐phenylene bis(2‐propylvalerate) ( 2 ) by an esterification reaction. The maximum shock seizure test for products 1 and 2 has been successfully carried out, and their cytotoxic activity and survival effects have also been carefully investigated.