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In vitro Evaluation of Carbon‐Based Nanospheres as Drug Delivery Vesicles in Breast Cancer Cell
Author(s) -
Kim Daehyun,
Kyung Hyuna,
Lee Seung Soo,
Park So Yeon,
Yoo Won Cheol,
Lee Hak Jong
Publication year - 2020
Publication title -
bulletin of the korean chemical society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.237
H-Index - 59
ISSN - 1229-5949
DOI - 10.1002/bkcs.11925
Subject(s) - paclitaxel , drug delivery , doxorubicin , docetaxel , drug , gemcitabine , breast cancer , cancer , cancer research , cancer cell , in vitro , nanotechnology , pharmacology , materials science , chemistry , chemotherapy , medicine , biochemistry
The application of nanoparticles in cancer treatment allows precise tumor treatment by enhancing drug delivery to the tumor area. To overcome limitations in the drug delivery system, we report carbon‐based nanospheres (CSs) that have high drug loading capacity as well as anti‐cancer effects. Monodisperse and size‐tunable (170–583 nm) CSs with excellent surface area up to 2619 m 2 /g provided high drug loading capacity in four different types of drugs (doxorubicin, gemcitabine, docetaxel, and paclitaxel), and demonstrated strong anti‐cancer effects against MDA‐MB‐231 human breast carcinoma cells.