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Lithium tert ‐Butoxide‐catalyzed Hydroboration of Carbonyl Compounds
Author(s) -
Kim Jea Ho,
Jaladi Ashok Kumar,
Kim Hyun Tae,
An Duk Keun
Publication year - 2019
Publication title -
bulletin of the korean chemical society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.237
H-Index - 59
ISSN - 1229-5949
DOI - 10.1002/bkcs.11855
Subject(s) - hydroboration , chemistry , lithium (medication) , catalysis , organic chemistry , medicine , endocrinology
We report the successful hydroboration of aldehydes and ketones with pinacolborane using 1 mol % lithium tert ‐butoxide under ambient conditions. The present protocol was applicable to various aldehydes and ketones, and the corresponding boronate esters and subsequent alcohols were obtained in good to excellent yields. In addition, this high‐yielding practical method could be extended to the reduction of ester groups. Under optimized conditions, LiO t Bu facilitate the hydroboration of ester groups quantitatively.